Generic alternatives may be available. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. $25 or less cost for commercially insured patients on the Auvi-Q website (through the direct delivery service or pick up at Walgreens). Call 844-357-3968 for offer eligibility questions. Ask your doctor or pharmacist to show you and any of your caregivers who could be injecting the medication how to use the prefilled automatic injection device. About $650-$700 cash price (two auto-injectors). Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Epinephrine Injection: MedlinePlus Drug Information (2017). If youre paying out of pocket without insurance, youll want to check online for pharmacy coupons to help with the costs. The EpiPen, an easy-to-use injectable shot filled with medicine that can stop a life-threatening allergic reaction, has increased in price from about $100 for a pack of two pens in 2009 to over $600 this year. Anaphylaxis is a severe and potentially life threatening consequence of an allergic reaction. Be sure to ask your pharmacist or doctor if you or your caregivers have any questions about how to inject this medication. Your doctor may tell you to use epinephrine injection even if you are allergic to one of the ingredients because it is a life-saving medication. View our instructional How-To-Use video and other training resources. Antihistamine medications, such as diphenhydramine (Benadryl) or loratadine (Claritin), can be used to manage allergy symptoms. Included is detail on how they work and the typical costs involved. An EpiPen is a device used to quickly deliver the medication epinephrine to someone whos experiencing anaphylaxis. QBlDb L+LC|"-F^ |"l+Uf5TsR1xYY|wr JE)3u6H?ypT O$o>>U2F -fyAt%dIq:|0 You may need further medical attention. Available for Android and iOS devices. Sign up now to stay in the know with the latest product updates! tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Preexisting hypertension; occlusive vascular disease; angle-closure glaucoma (eye drops); hypersensitivity; cardiac arrhythmias or tachycardia. The agency requires appropriate data and information to demonstrate that complex drug-device combination products meet the FDAs rigorous approval standards to ensure quality drug products that are safe and effective are available to patients. Uses Before taking Warnings Side effects Overdose Dosage FAQ Uses of EpiPen: hbbd``b`~$@;`4? Be sure to also tell your healthcare professional all the medicines you take, especially medicines for asthma. When anaphylaxis is suspected, epinephrine solution should be given as soon as possible as an intramuscular injection, in the middle of the outer side of the thigh, which corresponds to the location of the vastus . Discard epinephrine auto-injectors after one use. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. However, bringing an epinephrine auto-injector over the border from Canada into the U.S. may be questioned and your medication may be confiscated by customs officials at the border. The American Society of Health-System Pharmacists, 4500 East-West Highway, Suite 900, Bethesda, Maryland. Adrenaclick is expensive, running close to $500 per two-pack. To ensure you receive proper treatment when you need it most, its best to replace your pens before they expire. Use EPIPEN(epinephrine injection, USP) 0.3 mg or EPIPEN JR(epinephrine injection, USP) 0.15 mg Auto-Injectors right away when you have an allergic emergency (anaphylaxis). Gangrene, tissue necrosis and sloughing (extravasation) when used in addition to local anaesthetics. Place the tip of the auto-injector against the largest part of the outer thigh. Study Suggests It's Covered in Allergens, medications to increase your blood pressure. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. However, if exposure does occurs, an auto-injectable epinephrine like EpiPen is used to help prevent anaphylaxis and should be given quickly. The EpiPen Outrage Continues. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. You are encouraged to report negative side effects of prescription drugs to the FDA. Sneader W. The discovery and synthesis of epinephrine. Anaphylaxis (pronounced "ana-fi-LAX-is") is an medical emergency due to a severe allergy and may result in symptoms such as: One brand name EpiPen or EpiPen Jr. package (which contains 2 auto-injectors) will cost roughly $650 to $700 if you are paying cash, although pharmacy coupons or manufacturers discounts may lower the price. There is already less blood flow to the hands and feet, and epinephrine could make that worse and cause damage to these tissues. Be sure that you know how to inject the second dose and how to tell whether you should inject a second dose. The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. Coupon may be needed. Stay with the person and continue to reassure them until help arrives. Medically reviewed by Drugs.com on Aug 27, 2021. Last medically reviewed on April 20, 2022. This list is not complete. Biphasic anaphylaxis is a secondary anaphylactic reaction. %8D%va@- X 0H(y":K)vIBoh]fZpvhT*:B<4&/]%*~-Y&pt4UBYfOi.qfk^*!''*@YIT,'d[O8jl Ucn[7Xq&}6|U.&mZ,H(Ut.xtqw%1FY%y9H0@:Kgqo8-T>`7],UoG}tQ,gN]UHgP||4fBbT)E,zV{?lm\d+'k\Z@x[tu8=z*5BQj>.&k7vh4*seS~y68m^*f+jS2ZduE-AAlN ]7]7uj&Fj$gtmNjAiKb# Impax: Generic Epinephrine Auto-Injector Available - MPR Continue reading, If someone is having an anaphylactic reaction, and all you have on hand is a recently expired EpiPen, then use it so long as it is not discolored and does not contain any particles. EPIPEN and EPIPEN JR are intended for immediate administration as emergency supportive therapy only. EPIPEN, EPIPEN JR, EPIPEN 2-PAK, EPIPEN JR 2-PAK, EPIPEN4SCHOOLS, NEVER-SEE-NEEDLE, LIFE HAPPENS. Practical information. 3A|j Antihistamines cant treat anaphylaxis on their own. If its really that important, then I suggest you pack an epinephrine 1mg/ml ampule and a 1cc syringe. Information is also available online at https://www.poisonhelp.org/help. Through the Kaleo Patient Assistance Program, eligible patients who do not have commercial insurance and who are experiencing financial difficulties may be able to receive Auvi-Q at no cost. Epinephrine injection is used to treat severe allergic reactions (anaphylaxis) to insect stings or bites, foods, drugs, and other allergens. Learn why its crucial to visit. The EpiPen is intended to automatically inject a dose of epinephrine into a persons thigh to stop an allergic reaction. The following are the requirement to be eligible to use the EpiPen Savings Card: This offer that can provide you up to $300 savings for each EpiPen 2-Pak carton per prescription refill (a maximum of six 2-pack cartons per year). Other drugs may affect epinephrine, including prescription and over-the-counter medicines, vitamins, and herbal products. To enroll, patients must complete the patient assistance program form with their physician. People use artificial epinephrine as a medication to treat severe allergic reactions. People may wonder if they should administer epinephrine if they suspect but aren't sure that they are having an anaphylactic reaction. If you use Medicare, youll want to learn more about what coverage includes. Inject only into the muscle of the outer thigh, never into a vein. In an emergency, this injection can be given through your clothing. In August 2016 two U.S. senators questioned why there had been such a massive EpiPen price increase by Mylan, the manufacturer of EpiPen at the time. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. EpiPens can remain unused for long periods of time, so many patients wonder how long an EpiPen can last before it expires. What should I know about storage and disposal of this medication? It is only available with a prescription. However, costs can vary based on the distributor and based on whether you use a mail-order or in-person pharmacy. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. For example, the authorized generic for EpiPen is the same drug (therapeutically equivalent) and the same device; however, the packaging states epinephrine on the label instead of EpiPen. Epinephrine belongs to a class of drugs called alpha-adrenergic and beta-adrenergic receptor agonists. PDF EPIPEN (epinephrine); EPIPEN Jr (epinephrine) Label - Food and Drug Sometimes the person may need a second dose (requiring an additional auto-injector) should they not respond effectively to the first dose. In the U.S., you cannot buy EpiPen unless you have a prescription from your doctor. Ask your doctor or pharmacist if you need help. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. These savings cards help eligible patients who have commercial health insurance save on out-of-pocket costs. Can you use an expired EpiPen in an emergency? Severe allergies can cause the throat to swell and close, preventing breathing. Please see the full Prescribing Information and Patient Information for EPIPEN. There are other more affordable alternatives to the EpiPen brand name product, including the authorized generic for EpiPen and EpiPen Jr. which can be purchased for roughly $200 for a two-pack, depending upon the pharmacy and if you use an online coupon. Do not try to reinsert an auto-injector a second time. This accounts for 0.4% of all Medicaid outpatient drug spending over the period. %A[8:JKX>>=2VAHU)5t-R:wWW]IDHA. Do not refrigerate epinephrine injection or leave it in your car, especially in hot or cold weather. endstream endobj startxref Using online coupons, consumers can get the authorized generic epinephrine auto-injector two-pack ranging from $150 to close to $400 at some pharmacies; again its worth checking around if you are a cash customer. Drugs.com. Do not put your thumb, fingers, or hand over the needle area of the automatic injection device. Epinephrine (Injection Route) Description and Brand Names - Mayo Clinic In this case, the FDA has published three draft or final guidances since 2009 related to the development of generic epinephrine auto-injectors. Do not use the extra liquid; dispose of the remaining liquid and device properly. It works within minutes to prevent progression and reverse the symptoms of anaphylaxis. According to the manufacturer, the three steps to using an EpiPen are: Call 911 or local emergency services, or have someone quickly take you to the nearest emergency room. 453 0 obj <>stream Concerns about pharmaceutical drug pricing have been rampant in the United States. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Patient education: Drug allergy (The Basics) Patient education: Allergy shots (The Basics) . Seek emergency medical attention after any use of epinephrine to treat a severe allergic reaction. Therefore, individuals should always follow the instructions on the device that their doctor has prescribed. Reber LL, et al. Plus many epinephrine products in the U.S. can now be found for roughly $110 or so. 2022 Viatris Inc. All Rights Reserved. Drug information provided by: Merative, Micromedex Along with its needed effects, a medicine may cause some unwanted effects. EpiPen Costs and Alternatives: What Are Your Best Options? When the symptoms of anaphylaxis begin, thats when the device is needed. Here, learn to recognize the symptoms and what to do next. Generic to EPIPEN. An authorized generic is made by the same manufacturer under their existing New Drug Application (NDA) already approved by the FDA. This information is not country-specific. The average U.S. retail price of a two-pack of brand name EpiPens is $669.82. How to Use an EpiPen: Instructions, Emergency Tips, and More - Healthline People who have allergies should carry an epinephrine auto-injector with them at all times. Note: Prices may vary depending on the pharmacy you visit, insurance or manufacturer price adjustments. At-home allergy tests are a convenient starting place if youre experiencing allergy symptoms. Training devices do not contain medication and do not have a needle. If not, speak to your pharmacist about getting a different injector with a longer expiration date. What special precautions should I follow? Dosage forms: injectable kit (0.1 mg; 0.15 mg; 0.3 mg; 1 mg/mL), injectable solution (0.1 mg/mL; 1 mg/250 mL-D5%; 1 mg/mL; 1 mg/mL preservative/sulfite-free; 10 mcg/mL-D5%; 16 mcg/mL-NaCl 0.9%; 2 mg/250 mL-D5%; 4 mg/250 mL-NaCl 0.9%), intravenous solution (10 mcg/mL-0.9%; 10 mcg/mL-D5%; 100 mcg/mL-NaCl 0.9%; 16 mcg/mL-D5%; 5 mg/250 mL-NaCl 0.9%) However, Adrenaclick also has an authorized generic epinephrine auto-injector and it can be obtained from some pharmacies for about $110 for a two-pack. It may be worthwhile to check with your insurance company before you get your prescription to find out which epinephrine product is covered. Description: Epinephrine, an active principle of the adrenal medulla, is a direct-acting sympathomimetic. If you need to administer epinephrine to another adult by using an auto-injector, follow the steps above and administer the injection into the upper thigh. Remove the injector from the thigh and gently rub the skin for 10 seconds. Signs of a serious allergic reaction include closing of the airways, wheezing, sneezing, hoarseness, hives, itching, swelling, skin redness, fast heartbeat, weak pulse, anxiety, confusion, stomach pain, losing control of urine or bowel movements, faintness, or loss of consciousness. Patients without insurance coverage can receive up to $100 off each prescription. This product is available in the following dosage forms: Solution; Before Using; Portions of this document last updated: Feb. 01, 2023 Because of this risk, they must carry an emergency dose of epinephrine at all times. Only a healthcare professional should give additional doses of epinephrine if you need more than two injections for a single anaphylactic episode. (Data includes prescriptions People with severe allergies should always carry an auto-injector with them in case of exposure to an allergen. After using an epinephrine injection, pregnant women should seek emergency medical attention. Learn more. You may need to use epinephrine during pregnancy or while you are breastfeeding. 2022 Viatris Inc. All Rights Reserved. Avoid or Use Alternate Drug. Other therapies used can include: What should you do in the event that someone is experiencing anaphylaxis? You can carry them in your handbag, laptop bag, or other carry-on luggage. Also, turn them on their side if theyre unconscious, pregnant, or having trouble breathing. Last medically reviewed on October 15, 2019. Consumer Reports.org. In addition, as with brand-name drugs, the FDA inspects manufacturing and packaging facilities for generic drugs to ensure that they are capable of consistently producing quality products. Some schools do stock the product for emergency use, but use in that setting would still be under the direction of a health care provider. The autoinjector contains a single dose of the drug for injection into the thigh. The cost of an EpiPen depends on how youre paying for it. It plays an important role in your body's "fight-or-flight" response. Patients greater than or equal to 30 kg (66 lbs) use the 0.3 mg strength and patients 15 to 30 kg (33 lbs to 66 lbs) use the 0.15 mg strength. hb```e``rf`a` @1V TP $]8M*g1k!#|\oY(&J_m]Q:sF3w&,b;8}gVq%IwAg?&Npd[',vm5W?86og3v#m7BV` %xlm[#|@Sg3q`h``` b 2"1@0 As anaphylaxis can be fatal, the benefits of epinephrine usually outweigh the risks. For example, take the EpiPen (epinephrine), an injectable medication required by people who have severe, life-threatening allergies (anaphylaxis). If the needle is bent from the first use, it may cause serious injury to your skin. Its simple design has allowed the EpiPen to dominate the auto-injector, Antihistamines are drugs that can relieve allergy symptoms such as runny nose, sneezing, and congestion. Epinephrine auto-injectors may be kept on hand for self-injection by a person with a history of severe allergic reaction. If you use a prefilled automatic injection device, be sure to get a replacement right away. Mylan's Authorized Generic to EpiPen. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. EpiPen's 500 Percent Price Hike Leaves Patients Scrambling Using an EpiPen can stop the symptoms of anaphylaxis and help stabilize you until help arrives. $95 to upwards of $300 for a 2-pack using cost-saving coupons. Do not inject this medicine into your hands or feet. Epinephrine injection comes as a prefilled automatic injection device containing a solution (liquid) and in vials to inject subcutaneously (under the skin) or intramuscularly (into the muscle). Side effects may be more likely in older adults. Many must keep more than one dose at hand. Epinephrine auto-injectors may be kept on hand for self-injection by a person with a history of severe allergic reaction. Amedra Pharmaceuticals. Following use of epinephrine injection, patients should seek immediate medical or hospital care. If theyre feeling nauseous or have vomited, gently turn them on their side. It is only for non-emergency use to practice giving yourself an epinephrine injection. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Viatris also offers an EpiPen patient assistance program for those who are eligible. Patient education: Using an epinephrine autoinjector (Beyond - UpToDate Both you and those close to you should learn to identify the symptoms of anaphylaxis and know how to administer an EpiPen injection properly. The FDA issued an Alert in June 2020 about malfunctions with the Adrenaclick device, so be sure to check any products you have on hand. Visiting time: at least 1 or 2 hours Opening days: the museum is open every day between June and September and closed every Monday the rest of the year. Learn more here about bee sting allergies. Youll still need to ask for medical help immediately. Because symptoms may reoccur, its not recommended that you drive yourself unless absolutely necessary. Dont use an adult EpiPen to treat children. It is especially important to use epinephrine when a person experiences anaphylaxis. Schedule: opening hours vary depending on the time of year. The labeling or packaging is, however, changed to remove the brand name or other trade dress. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Offer applies to two cartons of Auvi-Q per dose, per patient each calendar year. Use the medicine exactly as directed. Sept. 21, 2016 Accessed August 19, 2018. Other countries, such as Canada, have epinephrine auto-injectors available without a prescription at the pharmacy. Before prescribing the drug, they may test you for allergies and monitor your symptoms. The injection is given in the upper part of the thigh. For example, a 2017 study showed a significant drug breakdown after the expiration date and cited cases in which patients died from anaphylaxis after receiving a dose from expired EpiPens. The development of generic combination products can be more challenging than typical drug products, and the FDA regularly takes steps to help guide industry through the process. We comply with the HONcode standard for trustworthy health information. Always check your epinephrine injector at the counter when you pick it up from the pharmacy and make sure it has at least one year before expiring. Jan 19, 2017. Epinephrine injection is used along with emergency medical treatment to treat life-threatening allergic reactions caused by insect bites or stings, foods, medications, latex, and other causes. Overdose symptoms may include numbness or weakness, severe headache, blurred vision, pounding in your neck or ears, sweating, chills, chest pain, fast or slow heartbeats, severe shortness of breath, or cough with foamy mucus. Many of these steps were outlined in our Drug Competition Action Plan, announced last year. When a doctor prescribes epinephrine, it is important that they are aware of a persons full medical history. Tell your healthcare professional about all of your medical conditions, especially if you have asthma, a history of depression, thyroid problems, Parkinsons disease, diabetes, high blood pressure or heart problems, have any other medical conditions, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. If epinephrine is accidently injected into these areas, get emergency medical treatment immediately. Concerns existed that the drug was not priced fairly for patients with a life-threatening allergy without other options. These products can be hard to copy, and therefore sometimes dont face timely generic competition once patents and exclusivities are no longer a block to approval. Epinephrinesnap-EMS is used to treat severe allergic reactions ( anaphylaxis) to insect stings or bites, foods, drugs, and other allergens. The Star.com Accessed Apr 29, 2022 at, FDA Approves Symjepi. Vijayaraghavan R. (2020). Epinephrine injection helps to treat serious allergic reactions but does not take the place of medical treatment. The Savings Card is not considered health insurance. 18 years of age or older, resident of the U.S. Only valid for patients with commercial insurance, Not valid for patients who are covered by any state or federally funded healthcare program, Not valid if patient is Medicare eligible and enrolled in an employer-sponsored health plan or prescription benefit program for retirees, Not valid if the patients insurance plan is paying the entire cost of this prescription. Epinephrine should not be injected into the vein, buttock, fingers, hands or feet. This medicine comes with an autoinjector trainer and a separate trainer instructions for use. Not only do they not act as quickly as epinephrine, but they also cant effectively treat anaphylaxis by opening the airway or helping to raise your blood pressure. There is no need to undress, because the injector works through clothing. The generic is much cheaper but still expensive: $396.41. Update on the usage and safety of epinephrine auto-injectors 2017. Last updated on Nov 20, 2022. (the following information applies to both EPIPEN and its Authorized Generic), (the following information applies to both Epipen and its Authorized Generic), the Epinephrine Injection, USP Auto-Injector Savings Card, About If you experienced an anaphylactic event in the past, make sure to let the doctor know what happened. How to administer an EpiPen injection to a child, sciencedirect.com/science/article/pii/S0300957221001507, medlineplus.gov/druginfo/meds/a603002.html, epipen.com/-/media/files/epipen/howtouseepipenautoinjector.pdf, ncbi.nlm.nih.gov/pmc/articles/PMC5367766/, ncbi.nlm.nih.gov/pmc/articles/PMC5657389/, fda.gov/medical-devices/consumer-products/safely-using-sharps-needles-and-syringes-home-work-and-travel, ncbi.nlm.nih.gov/pmc/articles/PMC7243406/, Why Every Anaphylactic Reaction Requires a Trip to the Emergency Room, Everything You Should Know About Biphasic Anaphylaxis, Recognizing and Treating a Severe Allergy, Popular Over-the-Counter Oral Antihistamine Brands, Zara Risoldi Cochrane, Pharm.D., M.S., FASCP, The Most Common Allergies When Youre at the Beach, Are You Allergic to Your Smartphone? Epinephrine is in a class of medications called alpha- and beta-adrenergic agonists (sympathomimetic agents). The generic epinephrine auto-injector comes in 0.3 mg and 0.15 mg strengths. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Epinephrine injection, USP auto-injector. This serves as a safety feature and retracts the needle back into the device within seconds. If so, ask them if they need your help administering the injection. The price increase, from about US$94 for a two-pack of injectable epinephrine to more than $600 in just nine years, has members of Congress calling for investigations in how Mylan, the drug's . This approval means patients living with severe allergies who require constant access to life-saving epinephrine should have a lower-cost option, as well as another approved product to help protect against potential drug shortages. (2017). Seek emergency medical attention right away after using the injection. Continue reading, EpiPen, Adrenalin, Primatene Mist, Auvi-Q, +9 more. They and their loved ones should be familiar with how to use the device in emergency situations. These medications can relieve mild allergy symptoms, such as sneezing, itchy or watery eyes, and hives. This contains the correct dose of medicine your doctor has prescribed. It is important to check the epinephrine auto-injector regularly and replace it with a new one if: However, in an emergency, it is better to give an out-of-date epinephrine injection than to give none at all. Although not all of these side effects may occur, if they do occur they may need medical attention. You can bring your EpiPen onto a plane they are a common medical device and they should not cause any fuss when you are going through airport security. People should administer epinephrine within minutes of the onset of severe allergy symptoms. If you have certain medical conditions, or take certain medicines, your condition may get worse or you may have longer lasting side effects when you use EPIPENor EPIPEN JR. Common side effects include fast, irregular or pounding heartbeat, sweating, nausea or vomiting, breathing problems, paleness, dizziness, weakness, shakiness, headache, feelings of over excitement, nervousness or anxiety. FDA alerts patients and health care professionals of EpiPen auto-injector errors related to device malfunctions and user administration. Life-threatening allergies can include reactions to insect bites or stings, foods, medications, latex or other causes. Copyright 2023 MIMS. Canada, like the U.S., does have strict laws overseeing the safety of prescription medications. The EpiPen Jr device has a lower dosage of epinephrine, and if children receive too much epinephrine, it may hurt them. Epinephrine, also known as adrenaline, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions.Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been available . It's practically the same as epipen. The agency also is responsible for the safety and security of our nations food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products. Epinephrine, also known as adrenaline, is both a neurotransmitter and a hormone. See additional information. Ask your pharmacist any questions you have about refilling your prescription. 407 0 obj <> endobj VIATRIS and the Viatris Logo are trademarks of Mylan Inc., a Viatris Company. Following the advice below can help people use the device correctly and efficiently, maximizing its effectiveness. If your child has an allergic reaction and doesnt have an EpiPen Jr, youll want to use 911 or local emergency services as soon as possible. Look for online discount coupons or discount cards if paying cash out-of-pocket. Auto-injectors are also used with other medications. This branded product is no longer on the market. CNS effects; GI disturbances; epigastric pain; CV disorders; difficulty in micturition with urinary retention; dyspnoea; hyperglycaemia; sweating; hypersalivation; weakness, tremors; coldness of extremities; hypokalaemia. Help the person lie on their back. TCAs may induce hypertension and arrhythmia. for the Mercury on Oct. 17 . The website you are about to access is not owned or controlled by Viatris Inc. VIATRIS INC.
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